Sinusitis
Advancing Mechanistic Understanding of Sinonasal Inflammation and Disease Pathogenesis
Journal Mission
Sinusitis is a peer-reviewed, open-access journal dedicated to publishing rigorous research on the molecular mechanisms, cellular pathways, and pathophysiological processes underlying sinonasal inflammation and disease. Our mission is to advance mechanistic understanding of how sinusitis develops at the molecular and cellular levels, identify novel biomarkers for disease progression, and elucidate the fundamental biological processes that drive acute and chronic sinonasal inflammation.
As the paranasal sinuses—small, air-filled cavities within the facial bones—become inflamed through complex immunological and inflammatory cascades, understanding these underlying mechanisms becomes critical for developing targeted interventions. Sinusitis provides a scholarly platform for researchers investigating disease pathogenesis, inflammatory mediators, host-pathogen interactions, and the molecular basis of mucosal dysfunction.
Research Scope & Pathophysiology Focus
Sinusitis focuses exclusively on pathophysiological mechanisms—the molecular and cellular basis of disease. We publish research on HOW sinusitis develops, progresses, and manifests at the biological level. Clinical management, treatment protocols, diagnostic algorithms, and patient care guidelines fall outside our scope.
The journal welcomes mechanistic investigations spanning molecular biology, immunology, microbiology, genetics, and systems biology as they relate to sinonasal inflammation. Our editorial board seeks manuscripts that deepen understanding of disease processes through rigorous experimental design, advanced analytical methods, and translational insights.
Inflammatory Pathways & Mediators
Cytokine signaling cascades, inflammasome activation, prostaglandin synthesis, leukotriene pathways, and molecular inflammatory networks in sinonasal mucosa.
Microbial Pathogenesis
Host-pathogen molecular interactions, bacterial biofilm formation mechanisms, viral entry pathways, fungal colonization dynamics, and microbiome dysbiosis at the cellular level.
Immunological Mechanisms
Innate and adaptive immune responses, T-cell differentiation pathways, antibody-mediated processes, immune tolerance breakdown, and molecular immunopathology.
Mucosal Biology & Barrier Function
Epithelial cell dysfunction, ciliary motility mechanisms, mucin production pathways, tight junction integrity, and cellular remodeling processes.
Biomarker Discovery & Validation
Molecular signatures of disease states, protein biomarkers, genetic markers, metabolomic profiles, and cellular indicators of inflammation progression.
Genetic & Epigenetic Factors
Genetic susceptibility variants, gene expression regulation, epigenetic modifications, DNA methylation patterns, and chromatin remodeling in sinusitis.
Cellular Signaling Pathways
Molecular signaling cascades, receptor-ligand interactions, intracellular signal transduction, transcription factor activation, and pathway crosstalk.
Disease Models & Experimental Systems
In vitro cell culture models, animal models of sinusitis, organoid systems, molecular imaging techniques, and experimental pathogenesis studies.
Article Types & Research Categories
Original Research
Novel mechanistic studies exploring molecular pathways, cellular mechanisms, biomarker identification, genetic associations, and experimental pathogenesis investigations using rigorous methodologies.
Review Articles
Comprehensive syntheses of current understanding in specific pathophysiological domains, systematic reviews of mechanistic evidence, and critical analyses of molecular research progress.
Mechanistic Insights
Focused reports elucidating specific molecular mechanisms, pathway analyses, cellular process discoveries, and translational pathophysiology findings.
Molecular Methodologies
Advanced technical approaches for investigating disease mechanisms, novel analytical methods, experimental model developments, and methodological innovations in pathophysiology research.
Manuscripts focusing on clinical diagnosis, treatment selection, therapeutic outcomes, patient management strategies, or clinical practice guidelines should be submitted to clinical or therapeutic journals. Sinusitis is dedicated exclusively to mechanistic understanding and pathophysiological investigation.
Editorial Standards & Peer Review
Sinusitis maintains rigorous editorial standards aligned with international publishing ethics guidelines. All submitted manuscripts undergo thorough peer review by experts in molecular mechanisms, cellular pathophysiology, and relevant research methodologies.
- Double-Blind Peer Review: Independent evaluation by specialists in sinonasal pathophysiology ensures objective assessment of mechanistic rigor and scientific validity.
- Methodological Scrutiny: Experimental design, analytical approaches, statistical methods, and data interpretation receive detailed evaluation for scientific soundness.
- Reproducibility Standards: Authors must provide sufficient methodological detail to enable replication, including protocols, reagents, and analytical parameters.
- Ethical Compliance: All research involving human tissues or animal models requires appropriate institutional review board approval and adherence to ethical guidelines.
- Data Transparency: Raw data availability, supplementary materials, and detailed methodology sections support transparency and scientific validation.
We are committed to efficient editorial processes while maintaining rigorous standards. Initial editorial decisions typically occur within 2-3 weeks of submission, with complete peer review cycles averaging 4-6 weeks for manuscripts entering review.
Benefits for Researchers
Open Access Impact
Immediate, unrestricted access to published research maximizes visibility, citation potential, and global dissemination of mechanistic discoveries to the scientific community.
Specialized Audience
Reach researchers, molecular biologists, immunologists, and translational scientists specifically interested in sinonasal pathophysiology and inflammatory disease mechanisms.
Rapid Publication
Streamlined editorial workflows enable prompt dissemination of important mechanistic findings while maintaining rigorous peer review standards.
Professional Support
Dedicated editorial assistance guides authors through submission, revision, and publication processes with responsive communication and clear expectations.
Submission Guidelines
Authors preparing manuscripts for Sinusitis should ensure their research focuses on mechanistic understanding, molecular pathways, cellular processes, or pathophysiological mechanisms. Manuscripts should clearly articulate how the research advances understanding of disease processes at the molecular or cellular level.
Consult our detailed Instructions for Authors for formatting requirements, reference styles, figure preparation guidelines, and submission procedures. Ensure compliance with ethical standards and data transparency requirements before submission.
Manuscripts can be submitted through our online submission portal. Authors are encouraged to contact the editorial office at [email protected] with questions regarding scope appropriateness, manuscript suitability, or submission procedures.
Contribute to Mechanistic Understanding of Sinusitis
Join the global community of researchers advancing pathophysiological knowledge of sinonasal inflammation. Submit your mechanistic discoveries to Sinusitis and contribute to the molecular understanding of this prevalent condition.
If you are uncertain whether your research aligns with our pathophysiology focus, please contact our editorial team at [email protected]. We welcome inquiries and can provide guidance on manuscript suitability before formal submission.
