Antioxidants in liver health examines how redox-active compounds protect hepatic tissue, the principal site of metabolism, detoxification, and biotransformation, against oxidative injury. The liver generates substantial reactive oxygen species through drug and xenobiotic processing, fatty-acid oxidation, and inflamm…
Antioxidants in liver health examines how redox-active compounds protect hepatic tissue, the principal site of metabolism, detoxification, and biotransformation, against oxidative injury. The liver generates substantial reactive oxygen species through drug and xenobiotic processing, fatty-acid oxidation, and inflammatory activity, and sustained oxidative stress contributes to hepatocyte damage, steatosis, inflammation, fibrosis, and progression toward cirrhosis. Endogenous defenses are prominent here, particularly glutathione, which is highly concentrated in hepatocytes, together with the enzymes superoxide dismutase, catalase, and glutathione peroxidase. Dietary and phytochemical antioxidants, including vitamin E, selenium, polyphenols, flavonoids, and plant polysaccharides, are studied for hepatoprotective potential, often in models of toxin- or diet-induced liver injury and in hepatic cell lines challenged with oxidants such as hydrogen peroxide. Research characterizes these compounds using radical-scavenging assays, total phenolic content, and total antioxidant capacity, and relates chemical activity to markers of liver function and oxidative damage. Significant scholarly questions concern the interplay between oxidative stress and mitochondrial dysfunction in chronic liver disease, the role of glutathione restoration in protection, and the degree to which antioxidant interventions translate into clinical benefit, since promising preclinical hepatoprotective effects do not consistently extend to human outcomes, keeping this an actively investigated field.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 84 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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