Research Topic · Peer-Reviewed

Scaffolds

In tissue engineering and regenerative medicine, scaffolds are three-dimensional structures that provide temporary physical and biological support for cells, guiding the formation and repair of tissue. They function as artificial extracellular matrices, offering a framework onto which cells attach, proliferate, diff…

Curated from this journal's research 📚 8 peer-reviewed articles cited Cited 344× across the literature 🔖 ISSN 2640-6403 🗓 Reviewed July 2026

Overview

In tissue engineering and regenerative medicine, scaffolds are three-dimensional structures that provide temporary physical and biological support for cells, guiding the formation and repair of tissue. They function as artificial extracellular matrices, offering a framework onto which cells attach, proliferate, differentiate, and organize, while permitting the diffusion of nutrients, oxygen, and signaling molecules and, ideally, degrading at a controlled rate as new tissue replaces them. The performance of a scaffold depends on its material composition, architecture, porosity, mechanical properties, and biocompatibility, and on its capacity to elicit a favorable rather than adverse biological response. A wide range of materials is used, including natural polymers such as chitosan and other biopolymers, synthetic biodegradable polyesters, and inorganic ceramics such as calcium orthophosphates that are particularly suited to bone regeneration. Fabrication strategies span techniques such as electrospinning to create fibrous matrices and three-dimensional printing to produce defined, patient-specific geometries. Scaffolds are applied across many tissue types, including bone, where they support repair of critical-sized defects, and neural tissue, where they can host stem cells and model regeneration after injury, and they are frequently combined with cells, including stem cells, and bioactive factors to enhance healing. By recreating aspects of the native tissue environment and directing cellular behavior, scaffolds are central to engineering functional tissue and advancing approaches to repair and regeneration.

Research published in this journal

8 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

The use of Dermacell® in Fingertip Injury

Bertasi GiampietroCorresponding author
University of Padua, Italy
Exact topic Clinical Case Reports and Images Cited by 6 doi:10.14302/issn.2641-5518.jcci-19-2626

How this research is being cited

The 8 articles above have been cited 344 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Scaffolds, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Tissue Repair and Regeneration (ISSN 2640-6403).

Journal editorial board
Walid Rachidi · France Ilaria Baldelli · Italy Costica Aloman · United States

This page summarises published research for orientation; it is not medical or professional advice.