The basement membrane is a thin, sheet-like layer of specialized extracellular matrix that underlies epithelial and endothelial cell layers and surrounds structures such as muscle and nerve fibers. Composed of proteins including type IV collagen, laminins, nidogen, and proteoglycans, it separates and anchors cell la…
The basement membrane is a thin, sheet-like layer of specialized extracellular matrix that underlies epithelial and endothelial cell layers and surrounds structures such as muscle and nerve fibers. Composed of proteins including type IV collagen, laminins, nidogen, and proteoglycans, it separates and anchors cell layers to the underlying connective tissue, provides mechanical support, and acts as a selective barrier that influences which molecules and cells can pass between tissue compartments. Beyond structural support, the basement membrane participates in cell adhesion, signaling, migration, and tissue organization, making it important in development, wound healing, and Tissue Repair and Regeneration. Defects in its components can cause serious disease: mutations affecting laminin subunits, for example, disrupt the attachment of the epidermis to the dermis and underlie blistering disorders. Within this journal's coverage of Tissue Repair and Regeneration, relevant work includes a trio study identifying a novel mutation in LAMB3, which encodes a laminin component of the basement membrane, as a cause of junctional epidermolysis bullosa, illustrating how the integrity of basement membrane proteins is essential to maintaining tissue structure. This page gathers peer-reviewed, open-access research relevant to the topic.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 44 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Basement Membrane, linking to each citing work.