Cell signalling is the system of molecular communication by which cells sense and respond to their environment and coordinate activity with one another. Signals such as hormones, growth factors, cytokines, and neurotrophic molecules bind receptors and trigger intracellular cascades, often involving second messengers…
Cell signalling is the system of molecular communication by which cells sense and respond to their environment and coordinate activity with one another. Signals such as hormones, growth factors, cytokines, and neurotrophic molecules bind receptors and trigger intracellular cascades, often involving second messengers and kinase networks, that regulate growth, differentiation, metabolism, immunity, and survival. Because signalling pathways integrate and transmit information, their disruption underlies many diseases, and they are a major focus of mechanistic and therapeutic research. Work in this area examines neurotrophic-factor-activated pathways in retinal Müller cells, interferon and chemokine signalling in tumour cells, and the role of chemokine receptors such as CXCR4 in breast-cancer metastasis. Studies also consider transcription-factor activation in inflammatory and keratinocyte responses, calcium and cyclic-nucleotide signalling, and proliferative and inflammatory pathways implicated in cancer and cardiovascular disease. Further research addresses the immune signalling of immunoglobulin responses, antioxidant effects in cardiomyoblast cells, and signalling relevant to stem-cell differentiation. By dissecting how receptors, messengers, and downstream effectors convey and process signals, cell-signalling research links extracellular cues to cellular behaviour, explains how communication failures drive disease, and identifies pathway components that can be targeted therapeutically, forming a core element of systems-level understanding of how cells and tissues operate.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 84 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Cell Signaling, linking to each citing work.