Research Topic · Peer-Reviewed

Single Strand Conformational Polymorphism Analysis

Single Strand Conformational Polymorphism Analysis (SSCP) is a genetic technique used for the detection of nucleotide sequence variations in DNA. It is based on the fact that a single-stranded DNA molecule adopts a variety of conformational states which are determined by its nucleotide sequence. SSCP can be used to …

Curated from this journal's research 📚 1 peer-reviewed article cited Cited 6× across the literature 🔖 ISSN 2326-0793 🗓 Reviewed July 2026

Overview

Single Strand Conformational Polymorphism Analysis (SSCP) is a genetic technique used for the detection of nucleotide sequence variations in DNA. It is based on the fact that a single-stranded DNA molecule adopts a variety of conformational states which are determined by its nucleotide sequence. SSCP can be used to distinguish among different DNA sequences due to the mobility shift that occurs when single-stranded DNA molecules with distinct structure move in a polyacrylamide gel. This technique is a powerful tool for characterizing mutations, particularly in regions of DNA that are difficult to clone or sequence, such as PCR amplicons or cDNA. It can also be used to identify polymorphic sequences in genomes or to detect the presence of unknown sequences. SSCP is a cost-effective, rapid, and sensitive method for detecting mutations, and it is advantageous for the analysis of large numbers of samples.

Research published in this journal

1 peer-reviewed article, ranked by relevance. Each links to its DOI.

How this research is being cited

The 1 article above has been cited 6 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Single Strand Conformational Polymorphism Analysis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Sutopa Dwivedi · United States Liuyang Wang · United States Juan Sainz · Spain

This page summarises published research for orientation; it is not medical or professional advice.