Protein expression is the cellular process by which genes are converted into functional proteins through transcription and translation, followed by folding and post-translational modification into mature, active molecules. It is controlled at multiple levels—transcriptional, translational, and post-translational—and…
Protein expression is the cellular process by which genes are converted into functional proteins through transcription and translation, followed by folding and post-translational modification into mature, active molecules. It is controlled at multiple levels—transcriptional, translational, and post-translational—and is frequently dysregulated in disease, making its measurement a central readout in molecular and cell biology. Recombinant and heterologous expression systems enable the production of proteins for research and biotherapeutic applications, while abundance is quantified through mass-spectrometry-based proteomics, including metabolic labeling approaches such as 15N SILAC and discovery and targeted quantification workflows, as well as complementary gene-expression methods. Study of expression in disease and stimulus-responsive models is a recurring theme: substrate stiffness governs the time-dependent expression of connective tissue growth factor in retinal Müller cells, transgenic models reveal isoform-specific expression of surfactant proteins SP-A1 and SP-A2 in the alveolar macrophage proteome, and altered expression underlies apoptosis resistance in colorectal cancer and differential response to agents such as lapatinib. Variant and regulatory analyses, including TREM2 and MS4A6A polymorphisms, regulatory single-nucleotide polymorphisms in EPAS1, and coronary-disease loci, link sequence to expressed protein levels. The journal publishes peer-reviewed research on expression regulation in disease models and on mass-spectrometry-based protein quantification.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 103 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Protein Expression, linking to each citing work.