Overview
Protein detection is the set of methods used to identify, quantify, and characterize specific proteins within biological samples such as tissues, cells, plasma, or culture media. Because proteins carry out most cellular functions and their abundance and modification states reflect physiological and disease conditions, reliable detection is fundamental to diagnostics, drug development, and basic research. Approaches span the proteome from single proteins to whole-body analysis and include immunoassays that exploit antibody recognition, electrophoretic separation, and, increasingly, mass spectrometry, which identifies and measures proteins and peptides by their mass-to-charge ratios. In Proteomics and Genomics Research, mass-spectrometry-based and chromatographic techniques enable both targeted measurement of individual proteins and comprehensive profiling of complex mixtures, supporting applications in cancer biology, biomarker discovery, and personalized medicine. Detection also extends to specific molecular features such as protein-protein and protein-DNA binding, post-translational modifications, and the conditions, including disulfide bonding, required for activity. Sensitivity, specificity, and reproducibility are central concerns, since low-abundance proteins and complex backgrounds challenge accurate measurement. The resulting data link protein expression to function and disease state, allowing researchers to use proteins as diagnostic and prognostic biomarkers and to monitor responses to treatment. By converting the presence and quantity of proteins into measurable signals, protein detection underpins the connection between molecular biology, clinical diagnostics, and therapeutic development.
Research published in this journal
9 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Human Proteome Project and Current Bioinformatics Status in Disease Diagnosis and Treatment
Rapid and Sensitive High-Performance Liquid Chromatography/Tandem Mass Spectrometry Method for Determination of Danshensu in Rat Plasma
The Novel Coronavirus 2019 (COVID-19): A Narrative Review
Dimerization of the BASIC PENTACYSTEINE Domain in Plant GAGA-Factors is Mediated by Disulfide Bonds and Required for DNA-Binding.
Correlation of Cryptococcal Antigen Assay with C-reactive Protein as Serum and Urine Biomarker in Cryptococcal Meningitis: Experience in a Tertiary Hospital
Acquired Abnormalities of Plasma Von Willebrand Factor Related Parameters and ADAMTS13 Autoantibodies in Aggressive Haematological Malignancies.
Carbofuran Abrogates the Membrane Ca++-Atpase Activity in Liver: The Role of Cholesterol
Proteome and Proteomics: from Single Protein to Whole Body
How this research is being cited
The 9 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2026 · Frontiers in Plant Science
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2026 · Bulletin of Biological and Allied Sciences Research
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Dina Ashraf Abdelhady et al. · 2025 · European Journal of Medical Research
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2025 · European journal of medical research
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2025 · Chemistry of Natural Compounds
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2025 · Chemical Communications
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2025 · Chemical Communications
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Shuai Zhang et al. · 2023 · Plant Stress
A sample of recent works citing this journal's research on Protein Detection, linking to each citing work.