The Human Proteome Project (HPP) is an international, coordinated effort to characterize the complete set of proteins encoded by the human genome, mapping their identities, abundances, modifications, interactions, and tissue and cellular distributions. Whereas the genome defines the potential repertoire of gene prod…
The Human Proteome Project (HPP) is an international, coordinated effort to characterize the complete set of proteins encoded by the human genome, mapping their identities, abundances, modifications, interactions, and tissue and cellular distributions. Whereas the genome defines the potential repertoire of gene products, the proteome reflects what is actually expressed, and the HPP aims to provide a comprehensive, evidence-based catalogue of human proteins to support biology and medicine. The project combines mass spectrometry-based and antibody-based approaches with extensive bioinformatic infrastructure to detect proteins, confirm those predicted but previously unobserved, and define their functional roles in health and disease. Research relevant to this topic includes work on the Human Proteome Project and the current bioinformatics status in disease diagnosis and treatment, broader perspectives on the proteome and proteomics from single proteins to the whole body, quantitative proteomic methods such as stable-isotope labeling, and analyses of disease-relevant protein responses. These examples illustrate the technical and analytical foundations on which proteome-wide characterization depends. By systematically resolving the human proteome, the HPP advances the discovery of biomarkers, the understanding of disease mechanisms, and the development of diagnostics and therapeutics, complementing genomic knowledge with a direct view of the molecular machinery that carries out cellular function.
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