Disease Proteomics

Overview

Disease proteomics is the study of the proteins involved in the onset, progression and treatment of disease, using large-scale protein analysis to identify disease-associated changes in abundance, modification and interaction and to translate them into diagnostic, prognostic and therapeutic insight. By comparing the proteomes of healthy and affected tissues or biofluids, it reveals dysregulated pathways, candidate biomarkers and potential drug targets, complementing genomic data with a direct readout of the functional molecular state. Methodologically it depends on mass-spectrometry-based discovery and quantification, isotope-labelling and ion-current-based strategies, and the integration of results with bioinformatic and genomic analysis. Research relevant to this area includes integrated proteomic and genomic techniques applied to cancer diagnostics and personalised medicine; the proteomics and bioinformatics status of the Human Proteome Project in disease diagnosis and treatment; analysis of plasma TREM2 and a genetic polymorphism in relation to liver enzymes in alcohol use disorder; methods for discovery and quantification in mass-spectrometry-based proteomics; quantitative proteomics using a 15N SILAC mouse; the proteomic response to targeted pharmacological treatment; bioinformatic analysis of disease-associated SNPs and genes in atherosclerosis; and reviews of molecular biomarkers. Foundational work on proteome coverage from single proteins to whole-body analysis supports the field. Collectively the literature advances biomarker discovery and mechanistic understanding across cancer, metabolic and cardiovascular disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 43 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Peripheral biomarkers of neuroinflammation in Alzheimer’s disease and vascular dementia
  2026 · Biochemical Pharmacology
• Association of peripheral blood NLRP3, sTREM2, and p-tau217 levels with cognitive outcomes in patients with chronic alcohol-related brain damage
  2026 · Alcohol and Alcoholism
• BDDN: bayesian dynamic differential network analysis in cancer proteomics
  2026 · BMC Bioinformatics
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  Hami Hemati et al. · 2025 · Brain, behavior, and immunity
• Improving T2D machine learning-based prediction accuracy with SNPs and younger age
  2025 · Computational and Structural Biotechnology Journal
• Investigation of Aldose Reductase Inhibitors: Implications for Therapeutic Targets in Diabetic Retinopathy
  2025 · Journal of Molecular Structure
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  2025 · Brain Behavior and Immunity
• Investigation of aldose reductase inhibitors: Implications for therapeutic targets in diabetic retinopathy
  2025 · Journal of Molecular Structure

A sample of recent works citing this journal's research on Disease Proteomics, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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