Coronary disease and myocardial infarction describe the pathological narrowing of the coronary arteries and its most acute consequence, the death of heart muscle from interrupted blood supply. Coronary artery disease develops when atherosclerosis, the progressive accumulation of lipid-laden plaque within arterial wa…
Coronary disease and myocardial infarction describe the pathological narrowing of the coronary arteries and its most acute consequence, the death of heart muscle from interrupted blood supply. Coronary artery disease develops when atherosclerosis, the progressive accumulation of lipid-laden plaque within arterial walls, narrows the vessels that perfuse the myocardium, reducing oxygen delivery and producing angina, ischemic heart disease, and impaired cardiac function. Myocardial infarction, commonly known as a heart attack, occurs when an unstable plaque ruptures and a thrombus abruptly occludes a coronary artery, causing irreversible necrosis of the territory it supplies. The disease arises from interacting risk factors, including dyslipidemia, hypertension, diabetes mellitus, smoking, obesity, physical inactivity, and genetic predisposition such as polymorphisms affecting lipid metabolism and coagulation. Diagnosis relies on clinical assessment, electrocardiography, cardiac biomarkers, coronary calcium scoring, and imaging that evaluates perfusion and ventricular performance, and untreated disease may progress to arrhythmia and heart failure. Because much of the risk is modifiable, prevention centers on lifestyle change and pharmacological control of lipids, blood pressure, and glucose, complemented by antithrombotic therapy and, when needed, revascularization. Research in this area examines genetic and metabolic determinants, the link with metabolic syndrome and diabetes, biomarkers including microRNAs, and preventive and therapeutic strategies to reduce cardiovascular morbidity and mortality.
6 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 6 articles above have been cited 22 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Coronary Disease/myocardial Infarction, linking to each citing work.