Research Topic · Peer-Reviewed

Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that selectively targets upper and lower motor neurons in the motor cortex, brainstem, and spinal cord, producing muscle weakness, wasting, spasticity, fasciculations, dysarthria, and dysphagia that advance to respiratory failure. Most ca…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 29× across the literature 🔖 ISSN 2474-3585 🗓 Reviewed July 2026

Overview

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that selectively targets upper and lower motor neurons in the motor cortex, brainstem, and spinal cord, producing muscle weakness, wasting, spasticity, fasciculations, dysarthria, and dysphagia that advance to respiratory failure. Most cases are sporadic, while a minority are familial and linked to mutations in genes such as C9orf72, SOD1, TARDBP, FUS, and OPTN (optineurin); converging pathogenic mechanisms include cytoplasmic mislocalization and aggregation of RNA-binding proteins, disturbed RNA metabolism, proteostatic and autophagy failure, mitochondrial dysfunction, oxidative stress, and glutamate excitotoxicity. ALS exists on a clinical and molecular continuum with frontotemporal dementia, and proteins of the RBM family and other RNA-binding factors are active subjects of structural, cellular, and evolutionary study. Environmental exposures, including the cyanobacterial neurotoxin beta-methylamino-L-alanine (BMAA), have been investigated as candidate contributors to motor neuron degeneration. Because disease-modifying options remain limited, management is largely supportive and multidisciplinary, encompassing respiratory support such as diaphragmatic pacing and noninvasive or mechanical ventilation, nutrition, and symptom control. The peer-reviewed research compiled here engages several of these strands, including the molecular biology and phylogenetics of RBM45, optineurin's regulatory roles, BMAA and cyanobacteria in ALS, and respiratory support strategies relevant to motor neuron disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2014

Understanding Ubl-Rpn1 Intermolecular Interaction

Pradhan N.Corresponding author
Sr. Professor and Head, Department of Psychopharmacology, NIMHANS, Bangalore, INDIA, 560001
Exact topic Advanced Pharmaceutical Science And Technology Cited by 7 doi:10.14302/issn.2328-0182.japst-13-288

How this research is being cited

The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Amyotrophic Lateral Sclerosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Preventive Medicine And Care (ISSN 2474-3585).

Journal editorial board
Heejung Kim · South Korea Monica Wang · United States Siddhartha Jonnalagadda · United States

This page summarises published research for orientation; it is not medical or professional advice.