Gram-negative bacteria are a major group of bacteria distinguished by a cell envelope that does not retain the crystal violet stain in the Gram staining procedure, owing to a thin peptidoglycan layer enclosed by an outer membrane containing lipopolysaccharide. This outer membrane acts as a permeability barrier that …
Gram-negative bacteria are a major group of bacteria distinguished by a cell envelope that does not retain the crystal violet stain in the Gram staining procedure, owing to a thin peptidoglycan layer enclosed by an outer membrane containing lipopolysaccharide. This outer membrane acts as a permeability barrier that contributes to their characteristic resistance to many antibiotics and disinfectants, while lipopolysaccharide (endotoxin) can trigger strong inflammatory and immune responses in the host. The group includes many ecologically important species as well as clinically significant pathogens such as Escherichia coli, Klebsiella, Salmonella, and Pseudomonas, which cause a wide range of infections. Research relevant to this topic in the journal addresses the detection, resistance, and effects of Gram-negative organisms, including carbapenem-resistance mechanisms in avian pathogenic Escherichia coli and in Klebsiella pneumoniae, the periodontal pathogen Porphyromonas gingivalis, and situational analyses of antimicrobial resistance. Further studies examine lipopolysaccharide-induced oxidative stress and tissue injury, antibacterial activity of natural and synthesized compounds, the bacteriological quality of groundwater, and pathogenic bacteria isolated from animal sources. Together these works highlight Gram-negative bacteria as agents of infection and antimicrobial resistance, as drivers of host inflammation through endotoxin, and as targets for diagnostics and novel antibacterial strategies.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 126 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Gram Negative Bacteria, linking to each citing work.