Research Topic · Peer-Reviewed

Lung Transplantation

Lung transplantation is the surgical replacement of one or both diseased lungs with healthy donor lungs to treat end-stage respiratory failure that no longer responds to medical therapy. It is offered for conditions such as chronic obstructive pulmonary disease, pulmonary fibrosis, cystic fibrosis, and pulmonary hyp…

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 18× across the literature 🔖 ISSN 2576-9359 🗓 Reviewed July 2026

Overview

Lung transplantation is the surgical replacement of one or both diseased lungs with healthy donor lungs to treat end-stage respiratory failure that no longer responds to medical therapy. It is offered for conditions such as chronic obstructive pulmonary disease, pulmonary fibrosis, cystic fibrosis, and pulmonary hypertension, and it can be performed as single-lung, double-lung, or, in selected circumstances, living-donor lobar procedures. The operation requires careful donor-recipient matching, management of ischemia during organ preservation, and lifelong immunosuppression to prevent rejection, which exposes recipients to infection and drug-related complications. Outcomes are shaped by primary graft dysfunction in the early period and by chronic lung allograft dysfunction over the longer term, alongside the surveillance of post-transplant complications through biopsy and imaging. As a form of solid-Organ Transplantation, it shares core challenges with heart, kidney, and other grafts, including personalized immunosuppression informed by genetic profiling, recognition of atypical post-operative syndromes, and the ethical and logistical questions of organ allocation and donation. Persistent pain and reduced quality of life can follow the procedure even when graft function is preserved, making symptom management part of long-term care. By restoring gas exchange, lung transplantation can extend survival and improve functional capacity for patients with otherwise terminal lung disease.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 10 articles above have been cited 18 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Lung Transplantation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Organ Transplantation (ISSN 2576-9359).

Journal editorial board
Francesca Diomede · Italy Luca Peruzzotti-Jametti · United Kingdom Karolina Golab · United States

This page summarises published research for orientation; it is not medical or professional advice.