Research Topic · Peer-Reviewed

Macular Degeneration

Macular degeneration is a progressive retinal disease that damages the macula, the central region of the retina responsible for high-acuity, detailed vision, leading to loss of central sight while peripheral vision is typically preserved. Its most common form is age-related macular degeneration, which exists as two …

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 70× across the literature 🔖 ISSN 2470-0436 🗓 Reviewed July 2026

Overview

Macular degeneration is a progressive retinal disease that damages the macula, the central region of the retina responsible for high-acuity, detailed vision, leading to loss of central sight while peripheral vision is typically preserved. Its most common form is age-related macular degeneration, which exists as two principal types. The dry, or atrophic, form is characterized by drusen deposits and gradual thinning and degeneration of the macula, whereas the wet, or neovascular, form involves the growth of abnormal choroidal blood vessels that leak fluid and blood, causing more rapid and severe visual loss. Pathogenesis involves oxidative stress, aging changes in the retinal pigment epithelium, choroidal vascular abnormalities, and angiogenesis driven by vascular endothelial growth factor. Management of neovascular disease relies on anti-VEGF therapy, and research examines persistent neovascular exudation in eyes with underlying choroidal pathology, as well as the contribution of imaging biomarkers to characterizing disease. Antioxidant nutrients and phytochemicals have been studied as potential means to slow progression of the atrophic form, and retinal Müller-cell signaling pathways are investigated for neuroprotection. The disease is a leading cause of central vision impairment, and its impact on quality of life makes early detection, monitoring, and effective treatment priorities for ophthalmic care.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 70 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Macular Degeneration, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Ophthalmic Science (ISSN 2470-0436).

Journal editorial board
Argyrios Tzamalis · GREECE Brian M. DeBroff · United States Emanuela Interlandi · Italy

This page summarises published research for orientation; it is not medical or professional advice.