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Oct 2022 DOI 10.14302/issn.2576-6694.jbbs-22-4179
Rammohan Chitra SubbiahCorresponding author
Head of Physics Department, P.K.N Arts and Science College, Tirumangalam in Madurai District, Tamilnadu, India
In this research work Mg0.45Mn0.55-xNixFe2O4 ferrite particles of varying compositions (x=0.05, x=0.15, x=0.25, x=0.45 and x=0.55) were synthesized using cost effectual co-precipitation route. The synthesized ferrite particles were characterized by collection of techniques. XRD analysis confirmed the formation of cubic spinel structure of the ferrite particles. SEM and AFM analyses illustrated the morphology and size distribution of obtained ferrite particles. FT-IR study exposed that the absence of any additional peak related to second phase. VSM results indicated magnetic analyses such as saturation magnetization (MS), Coercivity (HC) and Remanence (Mr) of ferrite particles. The major objective of the present investigation is to synthesize MgMnNiFe2O4 ferrite particles on cotton fabrics in order to obtain finished fabrics; it is very significant in biological applications. The antibacterial activities of the ferrite particles coated cotton fabrics were tested against selected Gram positive and Gram negative bacteria which showed tremendous results via formation of inhibition zones. The fabricated ferrite particles on cotton fabrics showed great durability evidenced by their antibacterial activities even after 20 washing cycles. Hence, the functionalized cotton fabrics could be used as potential antibacterial agent.
Jul 2024
Ndogo Eteme OlivierCorresponding author
Objectives Bacterial resistance to conventional antibiotics is a serious public health problem. Over the past decade, small proteins known as antimicrobial peptides (AMPs), natural compounds produced by all prokaryotic and eukaryotic cells have shown promising results in overcoming the growing problems of antibiotic resistance. There are nowadays several peptides of plant origin and rich in cysteines which have shown very good antimicrobial activities. The research of molecules with bactericidal activity is always current event with increase of multi resistance. The present study was undertaken to investigate the in vitro antibacterial activities of four synthesized peptides obtained in 97% yield by the solid phase synthesis method. Method The synthesis reaction was monitored by combined HPLC and LCMS methods and evaluation of the antibacterial property of these synthetized peptides. The antibacterial test was perform using micro dilution method on many species of bacteria, S. epidermidis ATCC 35984, S. aureus ATCC 25923, S. aureus ATCC 8095, E. faecalis ATCC 29212, E. faecium ATCC 700221, K. pneumoniae ATCC 700603, E. coli ATCC 25922, A. baumannii ATCC 19606, P. aeruginosa ATCC 27853. Results The conformity and effectiveness of the synthesis of the peptides was carried out by LCMS with an average yield of 91%. Peptides were bactericidal on almost all of these strains excepted E. coli ATCC 25922 where it was bacteriostatic. The biofilm eradication capacity test was carried out on two ATCC strains of S. epidermidis. Strain 35984 is a good biofilm-forming strain, while strain 12228 is considered a poor biofilm former. Comparison of the presence of biofilm between them showed a significant difference with p<0.05, showing that the controls used are significantly different in all cases. Conclusion Antimicrobial peptides are a good alternative today to fight against microbial resistance. In view of the results obtained, the different Neo peptides could serve as a basis for preclinical approaches to potential new active ingredients to combat certain microbial resistance.
May 2018 DOI 10.14302/issn.2473-1005.jdoi-18-2115
Zahoor MuhammadCorresponding author
Department of Chemistry, University of Malakand ChakdaraDir (Lower), Pakistan.
Background: The human mouth harbors over 700 microbial genera. The large number of them is normal bacteria; few of them are opportunistic pathogens. Objective: The study was aimed to evaluate the bacterial population of drug addicted persons and compare it to that of a normal healthy person. Methods: Five different samples of human saliva; alcohol drunken person, oral moist snuff user, cigarette, hashish and shisha smoker were investigated the involvement of bacteria in them. One sample was collected from normal non-addict person. The bacterial population in drug addictive persons were compared that on normal non-addictive person. Results: The bacteria observed were: Gram negative cocci, mono cocci, streptococci, vibrio, gram negative rod, gram positive staphylococcus, gram positive streptococci and gram-positive rod. Conclusion: The order of bacterial population was; alcohol drunken person<oral moist snuff user ˂ cigarette smoker ˂ hashish smoker ˂ shisha smoker˂ normal non addictive person. From the findings in this study it is concluded that all these drugs have some antibacterial activities.