Liquid-liquid extraction, also known as solvent extraction or partitioning, is a separation technique that distributes a substance between two immiscible liquids, usually an aqueous phase and an organic solvent, based on its relative solubility in each. As the mixture is shaken and allowed to settle, the target comp…
Liquid-liquid extraction, also known as solvent extraction or partitioning, is a separation technique that distributes a substance between two immiscible liquids, usually an aqueous phase and an organic solvent, based on its relative solubility in each. As the mixture is shaken and allowed to settle, the target compounds move preferentially into the phase in which they are more soluble, allowing them to be separated and purified from other components. It is a fundamental method in analytical, organic, and industrial chemistry, widely used for sample preparation, isolation of compounds, and the removal of impurities. Research in this subject area applies liquid-liquid extraction to the isolation and quantification of compounds from complex matrices. Studies have used the technique to extract and measure drugs such as opium-derived morphine and tramadol from biological samples, and have addressed extraction approaches in the analysis of contaminants of emerging concern. Liquid-liquid extraction is frequently combined with chromatographic and spectrometric methods for sensitive detection. This page gathers peer-reviewed, open-access research relevant to liquid-liquid extraction and its role in separation, purification, and chemical analysis in the broader study of New Developments in Chemistry.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 402 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Liquid-liquid Extraction, linking to each citing work.