High-performance liquid chromatography (HPLC) is an analytical technique used to separate, identify, and quantify the individual components of a chemical mixture. In HPLC, a liquid sample is injected into a stream of solvent, the mobile phase, and pumped under high pressure through a column packed with a finely divi…
High-performance liquid chromatography (HPLC) is an analytical technique used to separate, identify, and quantify the individual components of a chemical mixture. In HPLC, a liquid sample is injected into a stream of solvent, the mobile phase, and pumped under high pressure through a column packed with a finely divided stationary phase. As the mixture passes through the column, its components travel at different rates according to how strongly they interact with the stationary and mobile phases, allowing them to be separated and detected as they emerge. The technique is prized for its sensitivity, precision, and versatility, and it is widely applied in pharmaceutical analysis, food and environmental testing, clinical chemistry, and research. Research relevant to this topic includes a rapid and sensitive HPLC-tandem mass spectrometry method for determining a compound in rat plasma, an HPLC-UV method for quantifying atorvastatin calcium in pharmaceutical formulations, and the use of HPLC-MS/MS to measure a marker of oxidative DNA damage in human urine. Further work has applied chromatographic techniques to identify an adulterant in a dietary supplement and to develop new monolithic columns for separating small molecules. This page gathers peer-reviewed, open-access research relevant to chromatographic separation and chemical analysis.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 80 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on High Performance Liquid Chromatography, linking to each citing work.