Research Topic · Peer-Reviewed

Enzyme Inhibitors

Enzyme inhibitors are molecules that decrease or abolish the catalytic activity of enzymes by interfering with substrate binding or with the chemistry of the reaction. They are classified by their mechanism and reversibility: competitive inhibitors compete with substrate for the active site, noncompetitive and uncom…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 45× across the literature 🔖 ISSN 2377-2549 🗓 Reviewed July 2026

Overview

Enzyme inhibitors are molecules that decrease or abolish the catalytic activity of enzymes by interfering with substrate binding or with the chemistry of the reaction. They are classified by their mechanism and reversibility: competitive inhibitors compete with substrate for the active site, noncompetitive and uncompetitive inhibitors bind elsewhere to alter catalysis, and irreversible inhibitors form stable, often covalent, bonds with the enzyme. Because enzymes govern metabolic and signaling pathways, their inhibitors are widely exploited as drugs, agrochemicals, and biochemical tools. Examples span diverse targets, from plant alpha-amylase inhibition relevant to carbohydrate metabolism, to xanthine oxidase and peroxidase whose purification and characterization define inhibitor screening, to nucleoside and nucleotide reverse transcriptase inhibitors that block viral and telomerase-associated enzymes. In chemistry, the rational design and synthesis of inhibitors relies on understanding active-site architecture, binding kinetics, and structure-activity relationships, supported by synthetic strategies that generate candidate scaffolds such as glycosyl amides and related derivatives. Quantifying inhibition through kinetic parameters allows researchers to compare potency and selectivity. Advances in inhibitor design continue to drive applications in medicine, including cardiovascular and metabolic therapeutics, as well as in biotechnology and agriculture, where modulating enzyme activity offers precise control over biological and industrial processes.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 45 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Enzyme Inhibitors, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Annarita Del Gatto · Italy Bharat Gurale · United States Palani ELUMALAI · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.