Acylation

Overview

Acylation is a chemical reaction in which an acyl group is introduced into a molecule, typically replacing a hydrogen atom and forming a new carbon-nitrogen, carbon-oxygen, or carbon-carbon bond. This fundamental transformation is widely employed in organic synthesis to modify molecular structure and function. Research published in New Developments in Chemistry has explored acylation in the context of carbohydrate chemistry, particularly focusing on the synthesis of N-glycosyl compounds. Studies have investigated the formation of N-glycosyl amides through hydrolysis of protected glycosyl oxazolines and Ritter-like reactions using native carbohydrates, demonstrating practical routes to these nitrogen-containing glycosides. Additional work has examined the stereoselective synthesis of N-glycosyl oxazolines, compounds formed through intramolecular acylation processes, and evaluated their potential antiproliferative activity against cancer cell lines. These investigations highlight the importance of acylation reactions in constructing complex carbohydrate derivatives with defined stereochemistry, which may serve as valuable tools in medicinal chemistry and drug discovery. The ability to control acylation selectivity and apply these methods to both protected and unprotected carbohydrate substrates expands the synthetic toolkit available for generating biologically relevant molecules.

Research published in this journal

2 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 2 articles above have been cited 2 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Synthesis of N-Glycosyl Amides via Hydrolysis of Protected Glycosyl Oxazolines and Ritter-like Reactions of Native Carbohydrates
  2025 · Journal of New Developments in Chemistry
• Synthesis of N-Glycosyl Amides via Hydrolysis of Protected Glycosyl Oxazolines and Ritter-like Reactions of Native Carbohydrates
  2025 · Journal of new developments in Chemistry

A sample of recent works citing this journal's research on Acylation, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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