Atrophy is the wasting away, shrinkage, or decline in size and function of a cell, tissue, or organ, usually as a result of reduced cellular activity, loss of cells, or both. It can affect many parts of the body and arises from a range of causes, including disuse, loss of nerve supply, inadequate blood flow or nutri…
Atrophy is the wasting away, shrinkage, or decline in size and function of a cell, tissue, or organ, usually as a result of reduced cellular activity, loss of cells, or both. It can affect many parts of the body and arises from a range of causes, including disuse, loss of nerve supply, inadequate blood flow or nutrition, hormonal changes, aging, and disease. In the nervous system, atrophy refers to the loss of neurons and their connections or the shrinkage of brain regions, a feature of many neurodegenerative conditions; medial temporal lobe atrophy, for example, is associated with mild cognitive impairment and Alzheimer's disease. In muscle, atrophy reduces fiber size and strength and can result from immobilization, aging, or disease. Because atrophy often reflects an underlying process, identifying and measuring it, frequently through imaging, helps in diagnosis, in tracking disease progression, and in evaluating therapies aimed at preserving or restoring tissue. Within the scope of Neurological Research and Therapy, which addresses disorders of the nervous system and their treatment, this page gathers peer-reviewed, open-access research relevant to atrophy and neurodegeneration, including work on brain atrophy in cognitive impairment and Alzheimer's disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 40 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Atrophy, linking to each citing work.