The renin-angiotensin system (RAS) is a hormonal network that regulates blood pressure, fluid balance, and electrolyte homeostasis. It begins when the kidneys release the enzyme renin in response to factors such as low blood pressure or reduced sodium, setting off a cascade that produces angiotensin II, a potent hor…
The renin-angiotensin system (RAS) is a hormonal network that regulates blood pressure, fluid balance, and electrolyte homeostasis. It begins when the kidneys release the enzyme renin in response to factors such as low blood pressure or reduced sodium, setting off a cascade that produces angiotensin II, a potent hormone that narrows blood vessels and stimulates the release of aldosterone, which promotes sodium and water retention. Together these actions raise blood pressure. Because of its central role, the system is a major target for medications used to treat hypertension, heart failure, and kidney disease, including ACE inhibitors and angiotensin receptor blockers. Research relevant to this topic includes studies of the angiotensin-converting enzyme gene, such as an analysis of ACE insertion/deletion polymorphism in relation to obesity, blood pressure, and susceptibility to type 2 diabetes, and an investigation of the D allele and DD genotype of this polymorphism in patients with hypertension, stroke, and cancer. Further work has evaluated the efficacy and safety of a calcium channel blocker combination in hypertensive patients and explored microRNAs as potential tools in the diagnosis and treatment of hypertension. These studies connect the renin-angiotensin system to cardiovascular and renal health. This page gathers peer-reviewed, open-access research relevant to blood pressure regulation, hypertension, and the renin-angiotensin system.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 44 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Renin-Angiotensin System, linking to each citing work.