A tumour, or neoplasm, is an abnormal mass of tissue arising from the autonomous and excessive proliferation of cells that persists beyond the stimulus that provoked it. Tumours are broadly classified as benign, when they remain localised and well differentiated, or malignant, when they invade adjacent structures an…
A tumour, or neoplasm, is an abnormal mass of tissue arising from the autonomous and excessive proliferation of cells that persists beyond the stimulus that provoked it. Tumours are broadly classified as benign, when they remain localised and well differentiated, or malignant, when they invade adjacent structures and metastasise. Tumourigenesis is driven by genetic alterations affecting cell-cycle control, DNA repair, apoptosis, and senescence; loss of tumour-suppressor function, exemplified by p53, and dysregulation of cell-cycle regulators such as CDC6 can permit uncontrolled growth or, conversely, trigger protective senescence. Tumours encompass a vast spectrum of entities, from epithelial carcinomas and soft-tissue sarcomas to lipomatous, steroid-cell, nerve-sheath, and lymphoid Neoplasms, each with distinct histogenesis, imaging features, and differential diagnoses. Their study integrates molecular genetics, experimental models in vitro and in knockout animals, growth dynamics, and the influence of metabolic and dietary factors on proliferation and cell loss. Diagnosis relies on histopathology, imaging, and increasingly molecular characterisation. The peer-reviewed research collected under this topic addresses tumour growth dynamics, genes and senescence in tumour formation, rare and metastatic Neoplasms across multiple organ sites, p53-deficient models, and the cellular and metabolic determinants of tumour behaviour, reflecting the breadth of neoplastic pathology from molecular mechanism to clinical presentation.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 43 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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