Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, serving as a protective signal that alerts the organism to harm. It is conventionally classified by mechanism into nociceptive pain, arising from the activation of peripheral nociceptors; neuropathic pain, resul…
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, serving as a protective signal that alerts the organism to harm. It is conventionally classified by mechanism into nociceptive pain, arising from the activation of peripheral nociceptors; neuropathic pain, resulting from lesion or disease of the somatosensory nervous system, as in trigeminal or herpetic neuralgia; and nociplastic pain, reflecting altered central processing. Pain is further categorized by duration as acute or chronic, the latter persisting beyond expected healing and often becoming a disease state in its own right. Its perception involves transduction, transmission along ascending pathways, modulation by descending controls, and central interpretation shaped by cognitive and affective factors. Management is multimodal, encompassing pharmacological analgesia, interventional procedures, neuromodulation, and physical and psychological therapies. Research in this area addresses chronic low back pain treated with capsaicin patches, auricular vagus nerve stimulation and its effect on pain-related cytokines, music-induced analgesia through endogenous opioid production, synaptic and somatic plasticity underlying pain perception, balloon compression for trigeminal neuralgia, and clinical decision-support for analgesic dosing. The journal publishes peer-reviewed clinical and translational research spanning the mechanisms, assessment, and treatment of acute and chronic pain.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Pain, linking to each citing work.