Progressive-relapsing Multiple Sclerosis

Overview

Progressive-relapsing multiple sclerosis (PRMS) is an uncommon clinical course of multiple sclerosis characterized by steady neurological deterioration from the onset of the disease, punctuated by distinct acute relapses or flare-ups during which symptoms newly appear or existing ones worsen. It contrasts with the more common relapsing-remitting and primary-progressive forms, and under modern classification schemes the features it describes are often captured within active progressive disease. Like other forms of multiple sclerosis, it stems from immune-mediated damage to the myelin and nerve fibers of the central nervous system, and although there is no cure, treatment focuses on managing relapses, slowing progression, and preserving quality of life. Research into multiple sclerosis examines the vascular and neurological changes that accompany relapses and disease activity, as reflected in "Neurovascular Reactivity after Repeated Attacks in Patients with Multiple Sclerosis" (2017), which investigates how repeated attacks affect neurovascular function in affected patients. Such work contributes to understanding how relapses and ongoing progression shape the course of the disease. This page gathers peer-reviewed, open-access research relevant to progressive-relapsing multiple sclerosis and related disorders, supporting neurologists and researchers studying the mechanisms, course, and management of multiple sclerosis.

Research published in this journal

1 peer-reviewed article, ranked by relevance. Each links to its DOI.

This page summarises published research for orientation; it is not medical or professional advice.

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