Research Topic · Peer-Reviewed

Demyelination

Demyelination is the loss or damage of the myelin sheath, the lipid-rich insulating layer that surrounds axons in the central and peripheral nervous systems and enables rapid, saltatory conduction of nerve impulses. When myelin is destroyed, signal transmission slows or fails, producing neurological deficits that ra…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 41× across the literature 🗓 Reviewed July 2026

Overview

Demyelination is the loss or damage of the myelin sheath, the lipid-rich insulating layer that surrounds axons in the central and peripheral nervous systems and enables rapid, saltatory conduction of nerve impulses. When myelin is destroyed, signal transmission slows or fails, producing neurological deficits that range from sensory disturbance and weakness to visual loss and paralysis, depending on the tracts involved. Demyelinating disorders may be inflammatory and autoimmune, as in multiple sclerosis, infectious, toxic, metabolic, or hereditary, and recovery depends in part on the capacity for remyelination by oligodendrocytes and their precursors. The research gathered here addresses demyelination from several angles. Studies of multiple sclerosis examine vascular reactivity after relapses and atypical presentations such as cranial-nerve palsy in paediatric disease. Mechanistic work on the cells responsible for myelin includes oligodendrocyte development and the signalling pathways that govern it, central to understanding repair. Other contributions cover acquired and inherited demyelinating conditions, including progressive multifocal leukoencephalopathy, post-infectious acute disseminated encephalomyelitis, peripheral neuropathy, and metabolic disorders affecting myelin integrity such as Canavan and Tay-Sachs disease. Together these works frame demyelination as a unifying mechanism across diverse neurological diseases, and they reflect efforts to clarify how myelin is lost, how the nervous system attempts to restore it, and how the resulting disorders might be diagnosed and treated.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

The Novel Coronavirus 2019 (COVID-19): A Narrative Review

Rezapour BarataliCorresponding author
Department of Public Health, Faculty of Health, Assistant Professor, PhD in Health education and promotion, Urmia University of Medical Sciences, Urmia, Iran
Exact topic International Journal of Coronaviruses Cited by 2 doi:10.14302/issn.2692-1537.ijcv-20-3373

How this research is being cited

The 9 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Demyelination, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Multiple Sclerosis and Related Disorders.

Journal editorial board
Jorge Matias-Guiu · Spain Anne Vejux · France

This page summarises published research for orientation; it is not medical or professional advice.