Research Topic · Peer-Reviewed

Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor system characterized by the degeneration of upper motor neurons in the motor cortex and lower motor neurons in the brainstem and spinal cord. Loss of these neurons produces a combination of spasticity and hyperreflexia with m…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 29× across the literature 🗓 Reviewed July 2026

Overview

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor system characterized by the degeneration of upper motor neurons in the motor cortex and lower motor neurons in the brainstem and spinal cord. Loss of these neurons produces a combination of spasticity and hyperreflexia with muscle weakness, wasting and fasciculation, advancing to dysarthria, dysphagia, respiratory muscle failure and paralysis while often sparing sensory and oculomotor function. Most cases are sporadic, with a minority familial; converging molecular mechanisms implicate RNA-binding protein dysregulation and cytoplasmic protein aggregation, disrupted proteostasis, and excitotoxic and oxidative injury, and there is mechanistic overlap with frontotemporal degeneration. Diagnosis is clinical and electrophysiological with exclusion of mimics, and care is largely multidisciplinary and supportive, including respiratory and nutritional management. Work in this area includes the role of optineurin (FIP-2) in chemokine and kinase regulation, the molecular and evolutionary biology of the RNA-binding protein RBM45 and its protein-domain conservation, ubiquitin-like protein interactions relevant to proteostasis, a possible environmental link between cyanobacterial BMAA and ALS, and methodological work on blinding in neurological clinical research. The journal publishes peer-reviewed clinical and molecular research relevant to ALS and motor neuron degeneration.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2014

Understanding Ubl-Rpn1 Intermolecular Interaction

Pradhan N.Corresponding author
Sr. Professor and Head, Department of Psychopharmacology, NIMHANS, Bangalore, INDIA, 560001
Exact topic Advanced Pharmaceutical Science And Technology Cited by 7 doi:10.14302/issn.2328-0182.japst-13-288

How this research is being cited

The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Amyotrophic Lateral Sclerosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Multiple Sclerosis and Related Disorders.

Journal editorial board
Jorge Matias-Guiu · Spain Anne Vejux · France

This page summarises published research for orientation; it is not medical or professional advice.