Research Topic · Peer-Reviewed

Chromatin

Chromatin is the higher-order complex of DNA and protein that packages the genome within the eukaryotic nucleus. Its fundamental repeating unit is the nucleosome, in which roughly 147 base pairs of DNA wrap around an octamer of core histones, and these units fold into increasingly compact fibers that condense maxima…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 79× across the literature 🔖 ISSN 2577-2279 🗓 Reviewed July 2026

Overview

Chromatin is the higher-order complex of DNA and protein that packages the genome within the eukaryotic nucleus. Its fundamental repeating unit is the nucleosome, in which roughly 147 base pairs of DNA wrap around an octamer of core histones, and these units fold into increasingly compact fibers that condense maximally into chromosomes during cell division. Beyond packaging, chromatin is a dynamic regulator of genome function: its accessibility governs DNA replication, repair, and transcription, and is modulated by histone post-translational modifications, DNA methylation, ATP-dependent remodeling, and non-coding RNAs. Through these mechanisms chromatin establishes and maintains patterns of gene expression that direct cellular differentiation, development, and the response to environmental and disease states, and its dysregulation, the province of epigenetics, contributes to cancer and other disorders. Chromatin structure is therefore central to understanding how identical genomes give rise to diverse, regulated cellular phenotypes. The peer-reviewed research within this journal's corpus engages related molecular and cellular themes, including Wnt signaling in oligodendrocyte development, regulation of satellite-cell self-renewal involving microRNAs, computational analysis of regulatory single-nucleotide polymorphisms and transcription-factor binding sites, molecular control of human embryonic development, and signature proteins of eukaryotic cells. These reflect the broader study of gene regulation and cellular development within which chromatin biology is situated.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Robust Sampling of Defective Pathways in Parkinson Disease

Luis Fernández-Martínez JuanCorresponding author
Group of Inverse Problems, Optimization and Machine Learning. Department of Mathematics. C/ Federico García Lorca, 18. 33007 Oviedo. University of Oviedo. Spain
Exact topic Medical Informatics and Decision Making Cited by 2 doi:10.14302/issn.2641-5526.jmid-18-2529
2014

Bioinformatics of Metabolomics in Diabetes Mellitus Type 2

Ahmad Sliem HamdyCorresponding author
Biochemistry and internal Medicine*, Basic oral and medical sciences, College of dentistry, Qassim University, Saudi Arabia
Exact topic Bioinformatics And Diabetes Cited by 2 doi:10.14302/issn.2374-9431.jbd-13-212
2012

Eukaryotic Signature Proteins

Han JianCorresponding author
Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand
Exact topic Proteomics and Genomics Research Cited by 5 doi:10.14302/issn.2326-0793.jpgr-12-101

How this research is being cited

The 12 articles above have been cited 79 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Chromatin, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Human Anatomy (ISSN 2577-2279).

Journal editorial board
Randy Kulesza · United States Bing Guoying · United States Shuji Kitahara · Japan

This page summarises published research for orientation; it is not medical or professional advice.