Pathogenesis is the biological process by which an infection or disease develops, from the initial encounter between a pathogen and the host through the molecular and cellular events that produce tissue injury and clinical illness. For coronaviruses, a family of enveloped RNA viruses causing respiratory, gastrointes…
Pathogenesis is the biological process by which an infection or disease develops, from the initial encounter between a pathogen and the host through the molecular and cellular events that produce tissue injury and clinical illness. For coronaviruses, a family of enveloped RNA viruses causing respiratory, gastrointestinal, and neurological disease, pathogenesis begins with the spike glycoprotein mediating attachment and entry; in SARS-CoV-2 this involves binding to the angiotensin-converting enzyme 2 (ACE2) receptor and priming by host proteases, followed by genome replication, assembly, and release. Disease severity reflects the interplay between viral replication and the host response, in which dysregulated inflammation and cytokine release, endothelial injury, microvascular thrombosis, and immune-mediated damage contribute to pulmonary and systemic complications. Understanding pathogenesis links viral entry mechanisms, replication, and host immune dynamics to the spectrum of clinical outcomes and identifies targets for diagnosis and therapy. Pathogenic mechanisms are also studied across haematological, neoplastic, metabolic, and infectious diseases, where molecular and genetic analyses illuminate disease development. Research published in this area examines the mechanisms of coronavirus infection and disease alongside the pathogenesis of other conditions, reflecting the journal's coverage of how SARS-CoV-2 and related agents cause illness.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 140 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Pathogenesis, linking to each citing work.