Research Topic · Peer-Reviewed

Cytokines

Cytokines are small secreted signalling proteins that mediate and regulate immunity, inflammation, and haematopoiesis by binding specific cell-surface receptors and coordinating the behaviour of immune and tissue cells. The family includes interleukins, interferons, tumour necrosis factors, and chemokines, which act…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 35× across the literature 🔖 ISSN 2692-1537 🗓 Reviewed July 2026

Overview

Cytokines are small secreted signalling proteins that mediate and regulate immunity, inflammation, and haematopoiesis by binding specific cell-surface receptors and coordinating the behaviour of immune and tissue cells. The family includes interleukins, interferons, tumour necrosis factors, and chemokines, which act in autocrine, paracrine, and endocrine fashion to amplify or restrain immune responses. In viral infection, including COVID-19, balanced cytokine signalling supports antiviral defence, whereas excessive and dysregulated release, the so-called cytokine storm, drives hyperinflammation, tissue damage, and severe outcomes; pro-inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, IL-8, and IL-17 are recurrently implicated. Cytokine profiling characterises the inflammatory state of patients and informs prognosis and immunomodulatory treatment, and interferons have been studied as therapeutic immune modulators. The role of cytokines extends across pregnancy, metabolic and infectious disease, chronic pain, and inflammatory conditions, where their levels serve as biomarkers of disease activity. Research published in this area examines cytokine expression in coronavirus infection and other inflammatory states, interferon-based modulation, and the measurement of pro-inflammatory mediators, reflecting the journal's coverage of the immunological mechanisms underlying COVID-19 and related conditions.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

The Novel Coronavirus 2019 (COVID-19): A Narrative Review

Rezapour BarataliCorresponding author
Department of Public Health, Faculty of Health, Assistant Professor, PhD in Health education and promotion, Urmia University of Medical Sciences, Urmia, Iran
Exact topic International Journal of Coronaviruses Cited by 2 doi:10.14302/issn.2692-1537.ijcv-20-3373
2021

How this research is being cited

The 12 articles above have been cited 35 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cytokines, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Coronaviruses (ISSN 2692-1537).

Journal editorial board
Dr. Omeed Memar · USA Dr. SUDIPTI GUPTA · United States Dr. Jose Luis Turabian · Spain

This page summarises published research for orientation; it is not medical or professional advice.