Research Topic · Peer-Reviewed

Immunodeficiency

Immunodeficiency is a state in which the immune system's capacity to defend against infection and malignancy is impaired, arising either as a primary (inherited) defect in immune development or function or as a secondary (acquired) condition caused by infection, malignancy, malnutrition, or immunosuppressive therapy…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 23× across the literature 🔖 ISSN 2690-4721 🗓 Reviewed July 2026

Overview

Immunodeficiency is a state in which the immune system's capacity to defend against infection and malignancy is impaired, arising either as a primary (inherited) defect in immune development or function or as a secondary (acquired) condition caused by infection, malignancy, malnutrition, or immunosuppressive therapy. The most prevalent acquired cause is human immunodeficiency virus (HIV) infection, which progressively depletes CD4 T lymphocytes and predisposes to opportunistic infections, malignancies, and metabolic complications. Clinically, immunodeficiency manifests as recurrent, severe, or unusual infections and increased susceptibility to certain cancers, and its management combines treatment of the underlying cause, prophylaxis, immune reconstitution, and, in HIV, antiretroviral therapy. The peer-reviewed research in this area focuses substantially on HIV infection and its consequences, including drug resistance and baseline characteristics among antiretroviral-experienced children and adolescents, the cost and pattern of adverse drug reactions to antiretroviral therapy, opportunistic infection such as Saccharomyces fungemia in HIV, docking studies of phytocompounds against HIV enzymes, osteoporosis and CD4 correlation in HIV-infected patients, and sociocultural and adherence factors affecting prevention and care. Additional work addresses inherited immune dysregulation such as adenosine deaminase type 2 deficiency. Recurring themes include the immunological and clinical consequences of CD4 depletion, antiretroviral treatment and resistance, opportunistic infections and comorbidities, and the behavioral, social, and pharmacological dimensions of managing immunodeficiency across affected populations.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Pattern of Use of Highly Active Antiretroviral Therapy Regimens and Pattern of Occurrence of Adverse Drug Reactions in an Indian Human Immunodeficiency Virus Positive Patients

Rajesh RadhakrishnanCorresponding author
Radhakrishnan Rajesh M.Pharm, Asst Professor (Senior Grade), Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal- 576 104, Karnataka, India.
Exact topic Clinical Research In HIV AIDS And Prevention Cited by 1 doi:10.14302/issn.2324-7339.jcrhap-12-174

How this research is being cited

The 12 articles above have been cited 23 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Immunodeficiency, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Clinical Microbiology (ISSN 2690-4721).

Journal editorial board
Tonmoy Debnath · Taiwan A.C. Matin · United States Sandeep Misra · United States

This page summarises published research for orientation; it is not medical or professional advice.