Osteoblasts are the bone-forming cells responsible for synthesizing and depositing new bone matrix. Derived from mesenchymal stem cells, they produce the collagen-rich osteoid and direct its mineralization with calcium phosphate, building and renewing the skeleton. Osteoblasts work in coordinated balance with osteoc…
Osteoblasts are the bone-forming cells responsible for synthesizing and depositing new bone matrix. Derived from mesenchymal stem cells, they produce the collagen-rich osteoid and direct its mineralization with calcium phosphate, building and renewing the skeleton. Osteoblasts work in coordinated balance with osteoclasts, the cells that resorb bone, and this continuous remodeling maintains skeletal strength, repairs microdamage, and regulates the body's calcium and phosphate stores. As they finish forming bone, some osteoblasts become embedded in the matrix and mature into osteocytes that sense mechanical load, while others line bone surfaces. Disruption of osteoblast activity contributes to disorders of bone mass and quality, including osteoporosis, and osteoblast biology is central to bone healing and tissue engineering. Research within the International Journal of Bone and Mineral Metabolism engages with these cells directly, including an assessment of vitamin D3 effects on bone-health parameters using the human osteoblast cell line MG-63, and related work on calcium orthophosphate scaffolds for bone tissue engineering. Such studies probe how nutrients and biomaterials influence bone-forming cell function. This page gathers peer-reviewed, open-access research relevant to osteoblasts, bone formation, and the regulation of bone and mineral metabolism.
5 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 5 articles above have been cited 72 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Osteoblast, linking to each citing work.