Journal of Hypertension and Cardiology

The Open Access Pub has the reputation for quick reviewing and publishing original research articles. The editorial boards of our journals have many dedicated and reputed scientists as editorial members. Their support helps many researchers from all countries to enhance their research between scientists of various communities. This platform plays a crucial role in promoting science networks and exchanges.

Hypertension and Cardiology-Dr. Guchhait has long-standing interest in thrombosis and cardiovascular research.-Prasenjit Guchhait


Assistant Professor,
Thrombosis Research Division,
Cardiovascular Research Section.



Send an Email

Prasenjit Guchhait


Department of Medicine,
Baylor College of Medicine,
One Baylor Plaza, N1319.

Research Interests:

  • Dr. Guchhait has long-standing interest in thrombosis and cardiovascular research.
  • His research is focused on the complex mechanism of thrombosis, vasoocclusion and cardiovascular impairments in patients with sickle cell disease, thalassemia and hemolytic uremic syndrome.
  • He is working on the molecular mechanism that links intravascular-hemolysis and the above clinical events.
  • More specifically, how excessive extracellular hemoglobin promotes above clinical crises events under pathophysiological conditions.
  • His research describes that excessive extracellular hemoglobin blocks the cleavage of von Willebrand factor (VWF) and promotes accumulation of ultralarge VWF multimers in plasma and on endothelium.
  • The ultralarge VWF multimers are hyperactive and are associated with above clinical complications in patients.
  • His research also focused on identifying adhesive molecules on blood cells surface and on vascular endothelium that mediates unusual cell adhesion and culminate vascular occlusion in patients.
  • His research describe that increased exposure of adhesive membrane lipid, sulfatide on activated-platelet surface promotes platelets adhesion and thrombosis.
  • The increased exposure of sulfatide on sickled-red blood cells surface mimics the sickle cell adhesion to the endothelium and sub-endothelial matrices.
  • His research is also focused on translation of above molecular and genomic findings to therapeutic practice.
  • He has designed a recombinant small single-chain antibody against sulfatide that inhibits platelets adhesion to endothelium.
  • Currently in vivo experiments are in progress to determine the effects of anti-sulfatide scFvs on blood cells adhesion and vasoocclusion in mice with sickle cell disease.


  • PhD 1998, Banaras Hindu University
  • Postdoc at Baylor College of Medicine, USA
  • Instructor at Baylor College of Medicine, USA
  • Assistant Professor at Baylor College of Medicine, USA
  • Associate Professor at Regional Centre for Biotechnology, India