Research Topic · Peer-Reviewed

Factor V Leiden

Factor V Leiden is a genetic mutation in the Factor V gene that increases the risk of abnormal blood clot formation by making the blood more resistant to the natural anticoagulant protein C. This inherited thrombophilia represents the most common hereditary clotting disorder in populations of European descent. Resea…

Curated from this journal's research 📚 4 peer-reviewed articles cited Cited 7× across the literature 🔖 ISSN 2329-9487 🗓 Reviewed July 2026

Overview

Factor V Leiden is a genetic mutation in the Factor V gene that increases the risk of abnormal blood clot formation by making the blood more resistant to the natural anticoagulant protein C. This inherited thrombophilia represents the most common hereditary clotting disorder in populations of European descent. Research published in this journal has examined Factor V Leiden across multiple clinical contexts, including its role in branch retinal vein occlusion, where the mutation contributes to venous thrombotic events affecting retinal circulation. The journal has also addressed Factor V Leiden within comprehensive reviews of inherited bleeding and clotting disorders, exploring the genetic mutations affecting coagulation factors and regulatory proteins that govern hemostasis. Additional investigations have considered thrombophilic factors, including Factor V Leiden, in the context of sudden sensorineural hearing loss, examining whether prothrombotic conditions contribute to vascular compromise in the inner ear. The topic holds clinical significance because Factor V Leiden carriers face elevated risks for venous thromboembolism, and understanding this mutation informs risk stratification, screening decisions in affected families, and management strategies when additional thrombotic risk factors are present, such as pregnancy, surgery, or prolonged immobility.

Research published in this journal

4 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 4 articles above have been cited 7 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Factor V Leiden, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hypertension and Cardiology (ISSN 2329-9487).

Journal editorial board
Hatori Nobuo · Japan Gregor Leibundgut · Switzerland Yuejin Li · United States

This page summarises published research for orientation; it is not medical or professional advice.