Research Topic · Peer-Reviewed

Cardiovascular Disorders Heart Failure

Heart failure is a clinical syndrome in which structural or functional cardiac impairment prevents the heart from filling with or ejecting blood at a rate sufficient to meet the metabolic demands of the body, producing symptoms such as dyspnoea, fatigue, and fluid retention. It is commonly categorized by left ventri…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 63× across the literature 🔖 ISSN 2329-9487 🗓 Reviewed July 2026

Overview

Heart failure is a clinical syndrome in which structural or functional cardiac impairment prevents the heart from filling with or ejecting blood at a rate sufficient to meet the metabolic demands of the body, producing symptoms such as dyspnoea, fatigue, and fluid retention. It is commonly categorized by left ventricular ejection fraction into heart failure with reduced, mildly reduced, and preserved ejection fraction, and arises from cardiovascular disorders including coronary and ischaemic heart disease, long-standing hypertension, valvular and rheumatic disease, and cardiomyopathy. Its pathophysiology involves myocardial remodelling, neurohormonal activation of the renin-angiotensin-aldosterone and sympathetic systems, and cardiorenal interaction, whereby cardiac and kidney dysfunction reinforce one another. Within Hypertension and Cardiology, heart failure is studied as an end-stage consequence of diverse cardiovascular disorders, with research addressing cardiorenal signalling pathways, assessment of cardiac function including in models of induced cardiovascular disease and in vitro cardiomyocyte analysis, the contribution of hypertension and hypertensive crisis, valvular and rheumatic aetiologies, and haemodynamic responses to physiological stress such as isometric exercise. Regulatory mechanisms including microRNAs in ischaemic heart disease further inform understanding of pathogenesis and therapy. This topic gathers peer-reviewed research relevant to heart failure as a manifestation of cardiovascular disorders, encompassing its aetiology, cardiorenal and remodelling mechanisms, functional assessment, and links to hypertension and ischaemic disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 63 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cardiovascular Disorders Heart Failure, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hypertension and Cardiology (ISSN 2329-9487).

Journal editorial board
Hatori Nobuo · Japan Gregor Leibundgut · Switzerland Yuejin Li · United States

This page summarises published research for orientation; it is not medical or professional advice.