Research Topic · Peer-Reviewed

Atherosclerosis

Atherosclerosis is a chronic, progressive inflammatory disease of the arterial wall in which lipid-laden plaques accumulate within the intima, the innermost layer of medium and large arteries. It begins with endothelial dysfunction and the subendothelial retention and oxidation of low-density lipoprotein, triggering…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 70× across the literature 🔖 ISSN 2329-9487 🗓 Reviewed July 2026

Overview

Atherosclerosis is a chronic, progressive inflammatory disease of the arterial wall in which lipid-laden plaques accumulate within the intima, the innermost layer of medium and large arteries. It begins with endothelial dysfunction and the subendothelial retention and oxidation of low-density lipoprotein, triggering monocyte recruitment, foam-cell formation, smooth-muscle proliferation, and the deposition of a fibrous cap over a lipid-rich necrotic core. The resulting plaques narrow and stiffen the vessel lumen, restricting blood flow, while rupture or erosion of unstable lesions precipitates thrombosis, causing myocardial infarction, ischaemic stroke, and peripheral artery disease. Established risk factors include dyslipidemia, hypertension, diabetes, smoking, obesity, and genetic predisposition, and subclinical disease can be quantified non-invasively through measures such as carotid intima-media thickness. Studies in this area examine modifiable and non-modifiable risk factors, the use of carotid intima-media thickness as a marker of early arterial change, bioinformatic analysis of single-nucleotide polymorphisms implicated in coronary disease and atherosclerotic pathogenesis, the assessment of endothelial function, and the characterisation of lipid profiles. The field integrates vascular biology, immunology, lipid metabolism, genetics, and imaging to understand plaque initiation, progression, and the prevention of its life-threatening cardiovascular and cerebrovascular consequences.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Endothelial Function in Stroke Subtypes Using Endopat Technology

Enrique Jiménez Caballero PedroCorresponding author
Department of Neurology, San Pedro de Alcántara Hospital, Avenida de Pablo Naranjo nº 2, 10003. Cáceres. Spain.
Exact topic Neurological Research and Therapy Cited by 4 doi:10.14302/issn.2470-5020.jnrt-14-558

How this research is being cited

The 12 articles above have been cited 70 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Atherosclerosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hypertension and Cardiology (ISSN 2329-9487).

Journal editorial board
Hatori Nobuo · Japan Gregor Leibundgut · Switzerland Yuejin Li · United States

This page summarises published research for orientation; it is not medical or professional advice.