Overview
Aortic valve replacement is the treatment in which a diseased aortic valve, the one-way valve between the left ventricle and the aorta, is replaced to restore normal flow of oxygenated blood from the heart to the body. It is indicated chiefly for severe aortic stenosis, in which the valve narrows and obstructs outflow, and for significant aortic regurgitation, in which the valve fails to close and blood leaks back into the ventricle; both impose abnormal load on the heart and, when symptomatic or accompanied by ventricular impairment, warrant intervention. Underlying causes include calcific degeneration, congenital abnormalities such as a bicuspid valve, and rheumatic and other forms of valvular heart disease. Replacement may use a mechanical prosthesis, which is durable but requires lifelong anticoagulation, or a bioprosthetic valve from animal or human tissue, which avoids long-term anticoagulation but has a finite lifespan; the choice balances patient age, bleeding risk, and life expectancy. The valve can be implanted through conventional open surgery using cardiopulmonary bypass, or, increasingly, by transcatheter aortic valve implantation, a less invasive approach for selected patients. Procedural risks include infection, bleeding, conduction disturbance, and prosthesis-related complications. Preoperative imaging and cardiac assessment guide timing and technique. Research compares surgical and transcatheter approaches, prosthesis durability, and outcomes across the spectrum of valvular heart disease.
Research published in this journal
7 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Rheumatic Heart Disease In Chad: Clinical, Paraclinical, Therapeutic And Progressive Aspects
Human Myxomatous Mitral Valves Exhibit Focal Expression of Cartilage-Related Proteins
Ebstein's Anomaly With Right Atrial Thrombus in 23 Years Old Man at Reference National Teaching Hospital of Ndjamena: A Case Report.
Valvular Heart Disease and Pregnancy in the Delivery Room at Yalgado Ouedraogo University Hospital about 12 Cases
Apical Hypertrophic Cardiomyopathy and Multiple Coronary Artery-Left Ventricular Fistulas: A Case Report.
Assessment of Cardiac Function and Prevalence of Sleep Disordered Breathing using Ambulatory Monitoring with Acoustic Cardiography – Initial Results from SWICOS
How this research is being cited
The 7 articles above have been cited 12 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2023 · Biosensors
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2023 · Biosensors
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2022 · Frontiers in Cardiovascular Medicine
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2021 · Clinical Cardiology
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2021 · Clinical Cardiology
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2020 · Biomedical Engineering
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2020 · Journal of Histochemistry & Cytochemistry
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2020 · Biomedical Engineering
A sample of recent works citing this journal's research on Aortic Valve Replacement, linking to each citing work.