Adverse reactions, in pharmacology and clinical medicine, are unintended and harmful responses to a medicinal product occurring at doses normally used for prophylaxis, diagnosis, or therapy, and are the central subject of pharmacovigilance, the science of detecting, assessing, and preventing drug-related harm. They …
Adverse reactions, in pharmacology and clinical medicine, are unintended and harmful responses to a medicinal product occurring at doses normally used for prophylaxis, diagnosis, or therapy, and are the central subject of pharmacovigilance, the science of detecting, assessing, and preventing drug-related harm. They are commonly classified as Type A reactions, which are dose-dependent and predictable extensions of a drug's pharmacology, and Type B reactions, which are idiosyncratic or immune-mediated and not readily predictable from known pharmacological action; additional categories address chronic, delayed, withdrawal, and failure-of-therapy effects. Mechanisms span exaggerated on-target activity, off-target and receptor cross-reactivity, hypersensitivity and immunological responses, metabolic and pharmacogenetic variation, and drug-drug interactions. Adverse reactions are highly relevant to Hypertension and Cardiology, where antihypertensive and cardiovascular agents may produce effects such as electrolyte disturbance, conduction changes, hypotension, or thromboembolic risk, and where comorbidity and polypharmacy heighten exposure. Research in this area encompasses adverse-event surveillance across therapeutic classes, hypersensitivity and cross-reactivity phenomena, contrast-agent and procedural toxicity, drug-induced complications, and the broader assessment of toxicology and drug safety. This topic assembles peer-reviewed research relevant to adverse drug reactions, their classification and mechanisms, pharmacovigilance methods, and the safety considerations that inform rational prescribing in cardiovascular and general clinical practice.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 35 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Adverse Reactions, linking to each citing work.