Research Topic · Peer-Reviewed

Coagulation Factor Deficiencies

Coagulation factor deficiencies are disorders in which the absence, reduced level, or impaired function of one or more clotting factors compromises the body's ability to form a stable fibrin clot, producing a bleeding tendency that ranges from mild to life-threatening. The coagulation cascade depends on the sequenti…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 17× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Coagulation factor deficiencies are disorders in which the absence, reduced level, or impaired function of one or more clotting factors compromises the body's ability to form a stable fibrin clot, producing a bleeding tendency that ranges from mild to life-threatening. The coagulation cascade depends on the sequential activation of plasma proteins, and deficiency of any component disrupts thrombin generation and clot stabilisation. Inherited forms include haemophilia A and B, caused by deficiency of factors VIII and IX respectively and typically X-linked, and rarer autosomal disorders such as factor XI deficiency, also known as Rosenthal's disease or haemophilia C, which may present with mucosal bleeding such as chronic epistaxis. Deficiencies also arise from mutations affecting other coagulation factors and their regulatory proteins, underscoring the genetic heterogeneity of inherited bleeding disorders. Acquired deficiencies develop through autoantibody formation, as in acquired haemophilia, or secondary to liver disease, vitamin K deficiency, consumptive coagulopathy, and disturbances of von Willebrand factor and ADAMTS13 seen in haematological malignancy. Diagnosis combines clotting assays, factor-specific quantification, and inhibitor testing, while management uses factor replacement, bypassing agents, antifibrinolytics, and treatment of underlying causes. Research in this area characterises the molecular basis of factor defects, their clinical phenotypes, and improved strategies for prevention and control of bleeding.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 17 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Coagulation Factor Deficiencies, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.