Research Topic · Peer-Reviewed

Blood Coagulation Disorders

Blood coagulation disorders are conditions in which the haemostatic system fails to maintain the balance between clot formation and clot breakdown, producing either a tendency to abnormal bleeding or to pathological thrombosis. Normal haemostasis depends on the coordinated action of platelets, the coagulation factor…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 17× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Blood coagulation disorders are conditions in which the haemostatic system fails to maintain the balance between clot formation and clot breakdown, producing either a tendency to abnormal bleeding or to pathological thrombosis. Normal haemostasis depends on the coordinated action of platelets, the coagulation factor cascade, von Willebrand factor, and natural anticoagulant and fibrinolytic pathways; disruption at any point disturbs this equilibrium. Bleeding disorders may be inherited, arising from genetic mutations in coagulation factors and their regulatory proteins, as in the haemophilias and rarer deficiencies such as factor XI deficiency, or acquired, including abnormalities of von Willebrand factor and ADAMTS13 that accompany malignancy. Classification distinguishes defects of primary haemostasis involving platelets and von Willebrand factor from defects of secondary haemostasis involving the coagulation factors, and separates congenital from acquired causes. Hypercoagulable states, by contrast, predispose to venous and arterial thrombosis and arise in settings such as acute leukaemia and other systemic illnesses, while infections and organ disease can perturb coagulation through consumption, dysregulation, or altered factor synthesis. Diagnosis relies on coagulation assays, factor measurement, and molecular and immunological testing. The study of these disorders links haematology, molecular genetics, and clinical medicine to clarify mechanisms of bleeding and thrombosis and to guide diagnosis, monitoring, and targeted treatment.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 17 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Blood Coagulation Disorders, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.