Research Topic · Peer-Reviewed

Blood and Marrow Transplantation

Blood and marrow transplantation, also termed haematopoietic stem cell transplantation, is the infusion of haematopoietic progenitor cells to restore bone-marrow function and the blood and immune systems after disease or intensive therapy has destroyed the patient's own marrow. The transplanted stem cells may be col…

Curated from this journal's research 📚 7 peer-reviewed articles cited Cited 15× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Blood and marrow transplantation, also termed haematopoietic stem cell transplantation, is the infusion of haematopoietic progenitor cells to restore bone-marrow function and the blood and immune systems after disease or intensive therapy has destroyed the patient's own marrow. The transplanted stem cells may be collected from bone marrow, from peripheral blood after mobilisation with growth factors or agents such as plerixafor, or from umbilical-cord blood. Transplants are classified as autologous, using the patient's own previously harvested cells to permit high-dose chemotherapy, or allogeneic, using cells from a related or unrelated donor matched at the human leukocyte antigen loci. Allogeneic grafts additionally provide a graft-versus-tumour effect mediated by donor immune cells, but carry the risks of graft rejection, graft-versus-host disease, and profound immunosuppression with susceptibility to opportunistic infection. Donor-recipient HLA compatibility and pre-existing donor-specific antibodies critically influence engraftment and outcome. The procedure is used to treat leukaemias, lymphomas, myeloma, marrow-failure syndromes, and selected inherited and immune disorders. Conditioning regimens prepare the marrow and suppress host immunity before infusion, after which engraftment is monitored through blood-count recovery and chimerism. Complications, including infection, organ toxicity, and immune dysregulation, shape supportive care. Research addresses donor selection, mobilisation strategies, prevention of graft-versus-host disease, and management of post-transplant complications.

Research published in this journal

7 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 7 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Blood and Marrow Transplantation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.