Research Topic · Peer-Reviewed

Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the myeloid lineage of hematopoietic progenitor cells, defined by the uncontrolled proliferation and accumulation of immature myeloblasts within the bone marrow and peripheral blood. As these blasts expand, they crowd out and suppress normal hematopoiesis,…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 21× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Acute myeloid leukemia is an aggressive clonal malignancy of the myeloid lineage of hematopoietic progenitor cells, defined by the uncontrolled proliferation and accumulation of immature myeloblasts within the bone marrow and peripheral blood. As these blasts expand, they crowd out and suppress normal hematopoiesis, producing the cytopenias that dominate the clinical picture: anemia from impaired red-cell production, neutropenia that predisposes to serious and sometimes necrotizing infection, and thrombocytopenia that causes bleeding. The disease arises through leukemogenesis, the stepwise acquisition of somatic genetic mutations and recurrent cytogenetic abnormalities that disrupt the normal balance between proliferation, differentiation, and apoptosis in myeloid progenitors; surface molecules such as neuropilin-1 have been examined for their contributory roles. These acquired chromosomal and molecular lesions underpin disease classification and are central to prognostication and risk stratification. Distinguishing acute from chronic leukemias is fundamental, as their natural history and management differ substantially, and acute leukemia may also be accompanied by systemic complications including hypercoagulability and predisposition to thrombosis. Treatment is built upon intensive induction chemotherapy aimed at achieving complete remission, followed by consolidation and, in eligible patients, allogeneic hematopoietic stem-cell transplantation, which offers the prospect of cure. Transplantation itself carries hematologic and immune-mediated complications, including immune thrombocytopenia, that require ongoing specialized management.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603
2018

Molecular Biomarkers: A Brief Review

Tarassishin LeonidCorresponding author
 Department of Biological Sciences.
Exact topic Proteomics and Genomics Research doi:10.14302/issn.2326-0793.jpgr-18-2418

How this research is being cited

The 11 articles above have been cited 21 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Acute Myeloid Leukemia, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.