Overview
Positive-sense RNA viruses are a major group of viruses whose genetic material is a single strand of RNA that can act directly as messenger RNA. This means that once the virus enters a host cell, its genome can be read immediately by the cell's machinery to produce viral proteins, without first needing to be converted into a different form. This group includes many viruses of importance to human, animal, and plant health, among them the coronaviruses, such as SARS-CoV-2, the cause of COVID-19. Because their genome serves as a template for protein synthesis and replication, understanding the structure and behavior of positive-sense RNA viruses is central to developing diagnostics, antiviral treatments, and vaccines. Laboratory methods such as reverse-transcription PCR are commonly used to detect their RNA in clinical samples. Research published in this journal addresses the detection of such viruses, including a comparative analysis of commercial RT-PCR diagnostic assays for identifying COVID-19, which targets the RNA genome of a positive-sense RNA virus. This page sits within the peer-reviewed, open-access scope of the journal and gathers research relevant to positive-sense RNA viruses, viral diagnostics, and molecular virology.
Research published in this journal
1 peer-reviewed article, ranked by relevance. Each links to its DOI.