The testis is the male gonad, a paired organ housed within the scrotum that performs two essential functions: spermatogenesis, the production of spermatozoa within the seminiferous tubules, and the secretion of androgens, principally testosterone, by the interstitial Leydig cells. These activities are coordinated by…
The testis is the male gonad, a paired organ housed within the scrotum that performs two essential functions: spermatogenesis, the production of spermatozoa within the seminiferous tubules, and the secretion of androgens, principally testosterone, by the interstitial Leydig cells. These activities are coordinated by the hypothalamic-pituitary-gonadal axis and supported by Sertoli cells, which nurture developing germ cells and maintain the blood-testis barrier. Testicular function determines male fertility and the development and maintenance of secondary sexual characteristics, and it is vulnerable to oxidative stress, endocrine disruption, ischaemia-reperfusion injury, toxic and pharmacological insults, thermal and radiofrequency exposure, and systemic disease, all of which can impair spermatogenesis and steroidogenesis. Investigation of testicular biology employs histopathology, biochemical and molecular markers of steroidogenic gene expression and oxidative damage, and biopsy in the assessment of infertility, while experimental models examine protective and damaging influences on testicular tissue. The peer-reviewed research collected under this topic addresses structural changes in the testis induced by hypothyroidism and chemotherapeutic and toxic agents, oxidative stress and mitochondrial injury, the effects of plant extracts and bisphenol A on steroidogenesis and spermatogenesis, testicular morphology in infertile men, and the impact of radiofrequency exposure, reflecting the organ's central role in reproduction and endocrine function and the diverse factors that influence testicular health and male fertility.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 94 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Testis, linking to each citing work.