Research Topic · Peer-Reviewed

Male Infertility

Male infertility is the impairment of male reproductive capacity that prevents the establishment of a pregnancy, arising most commonly from defects in spermatogenesis, sperm quality and function, or the delivery of sperm. Normal male fertility depends on the integrity of the hypothalamic-pituitary-testicular (HPT) a…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 81× across the literature 🔖 ISSN 2576-2818 🗓 Reviewed July 2026

Overview

Male infertility is the impairment of male reproductive capacity that prevents the establishment of a pregnancy, arising most commonly from defects in spermatogenesis, sperm quality and function, or the delivery of sperm. Normal male fertility depends on the integrity of the hypothalamic-pituitary-testicular (HPT) axis, which governs hormonal control of sperm production, and on healthy testicular tissue capable of generating functional spermatozoa. Disruption at multiple levels can compromise fertility. Endocrine causes include perturbation of the HPT axis, as observed with hypothyroidism and with toxicant exposures such as the organophosphate dichlorvos. Oxidative stress is a recurrent mechanism: excess reactive oxygen species and impaired sperm mitochondrial function can damage sperm, and experimental insults such as lipopolysaccharide can induce testicular oxidative stress and apoptosis, while interventions including ozone therapy have been examined in relation to these pathways. Additional contributors encompass varicocele, genetic abnormalities, and structural or obstructive factors. Evaluation of the infertile male combines semen analysis to assess sperm concentration, motility, and morphology, hormonal profiling to characterize the endocrine axis, and, where indicated, testicular biopsy to examine seminiferous tubule morphology and the status of spermatogenesis. By integrating clinical, hormonal, and histological assessment, the workup aims to identify the underlying cause and to distinguish treatable conditions, framing male infertility as a multifactorial disorder of the male reproductive system.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 81 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Male Infertility, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Fertility Biomarkers (ISSN 2576-2818).

Journal editorial board
Reshef Tal · United States Weihua Wang · United States

This page summarises published research for orientation; it is not medical or professional advice.