Research Topic · Peer-Reviewed

Clinical Trials

Clinical trials are controlled studies in human volunteers conducted to determine whether a medical intervention is safe and effective and how it should be used. Governed by ethical principles, regulatory oversight, and rigorous methodology, they progress through phases that move from initial safety and dose-finding…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 14× across the literature 🔖 ISSN 2641-7669 🗓 Reviewed July 2026

Overview

Clinical trials are controlled studies in human volunteers conducted to determine whether a medical intervention is safe and effective and how it should be used. Governed by ethical principles, regulatory oversight, and rigorous methodology, they progress through phases that move from initial safety and dose-finding to comparative efficacy and post-marketing surveillance, employing randomization, blinding, predefined endpoints, and control groups to minimize bias and generate reliable evidence. Clinical testing is the necessary bridge between preclinical findings and approved practice, ensuring that new drugs, devices, and procedures are validated before market entry. The studies assembled here span the evidence ecosystem that supports and frames trials: systematic reviews and meta-analyses, including the effect of dairy consumption on vaccine immune response and the efficacy of targeted antibody therapy in HER2-positive gastric cancer; vaccine and cell-therapy development for COVID-19; gene-therapy perspectives for heart failure; and the clinical application of botanical agents for glycemic control. The historical use of blinding in neurological research and broad reviews of toxicology and drug-safety methodology situate trial conduct within safety science, while computational systems-toxicology work points to emerging predictive approaches. Methods include interventional and observational designs, evidence synthesis, and translational toxicity studies. This topic collects peer-reviewed research on clinical trial methodology, therapeutic evaluation, and the standards of evidence underpinning new interventions.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 14 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Clinical Trials, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Experimental and Clinical Toxicology (ISSN 2641-7669).

Journal editorial board
Roy Gerona · United States Bulent Uysal · United States Ichiro Kawahata · Japan

This page summarises published research for orientation; it is not medical or professional advice.