Cardiac toxicity refers to damage or dysfunction of the heart muscle and its associated structures caused by exposure to chemical substances, drugs, or other toxic agents. Research published in Experimental and Clinical Toxicology on this topic addresses both the development of testing methodologies and the investig…
Cardiac toxicity refers to damage or dysfunction of the heart muscle and its associated structures caused by exposure to chemical substances, drugs, or other toxic agents. Research published in Experimental and Clinical Toxicology on this topic addresses both the development of testing methodologies and the investigation of specific cardiotoxic mechanisms. The journal has examined the role of in vitro disease models as tools for preclinical assessment of cardiotoxicity and safety evaluation, contributing to the broader landscape of methods used to predict cardiac adverse effects before human exposure. Additionally, published work has explored cellular mechanisms of drug-induced cardiac damage, including studies on how certain compounds can reduce heart cell injury caused by local anesthetic agents like bupivacaine hydrochloride. This research area is significant because cardiac toxicity represents a major concern in drug development and clinical medicine, as it can lead to serious adverse events including arrhythmias, heart failure, and sudden cardiac death. Understanding the mechanisms underlying cardiotoxic effects and developing reliable preclinical testing strategies are essential for improving drug safety profiles and protecting patient health across therapeutic areas.
2 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 2 articles above have been cited 1 time in the scholarly literature. Citation data via OpenAlex and Crossref, updated Oct 2025.
A sample of recent works citing this journal's research on Cardiac Toxicity, linking to each citing work.