Research Topic · Peer-Reviewed

Stem Cells Development

Stem cell development refers to the processes by which stem cells proliferate, commit to particular lineages, and differentiate into specialized cell types, together with the molecular signals that regulate these transitions. Stem cells are defined by self-renewal and potency, the capacity to generate one or more di…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 42× across the literature 🔖 ISSN 2574-4372 🗓 Reviewed July 2026

Overview

Stem cell development refers to the processes by which stem cells proliferate, commit to particular lineages, and differentiate into specialized cell types, together with the molecular signals that regulate these transitions. Stem cells are defined by self-renewal and potency, the capacity to generate one or more differentiated cell types, and their development is governed by transcription factors, signaling pathways, epigenetic regulation, and microenvironmental cues. Understanding this regulation is central to using stem cells in research, disease modeling, and regenerative strategies. Diverse stem cell populations illustrate developmental control. Mesenchymal stem cells, including adipose-derived cells, can be directed toward therapeutic applications such as ovarian aging and tissue repair, while specialized niches such as hypothalamic stem cells express lineage-relevant receptors. Post-transcriptional regulation by microRNAs, for example targeting the pluripotency factor OCT4, shapes self-renewal and commitment, and neural stem cells display context-dependent responses, including neuroprotection or neurotoxicity under pharmacological exposure and autophagy-linked mechanisms. Induced pluripotent stem cell-derived cardiomyocytes provide developmental models for functional assays and safety testing, and cancer stem cells reveal how developmental programs can be co-opted in disease. Studies of hematopoietic disruption further show how injury alters lineage development. Investigating stem cell development thus clarifies how potency is maintained or resolved into specialized fates, underpinning both fundamental cell biology and translational efforts in regenerative medicine.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Stem Cells Development, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Evolving Stem Cell Research (ISSN 2574-4372).

Journal editorial board
Takafumi Yokota · Japan Chiara Raggi · Italy Morikuni Tobita · Japan

This page summarises published research for orientation; it is not medical or professional advice.