Pluripotent stem cells are cells with the capacity to self-renew and to differentiate into the many specialized cell types of the body's three primary germ layers. They include embryonic stem cells and induced pluripotent stem cells (iPSCs), the latter generated by reprogramming adult somatic cells, and they are cen…
Pluripotent stem cells are cells with the capacity to self-renew and to differentiate into the many specialized cell types of the body's three primary germ layers. They include embryonic stem cells and induced pluripotent stem cells (iPSCs), the latter generated by reprogramming adult somatic cells, and they are central to regenerative medicine, disease modelling and drug discovery because they can in principle supply almost any cell type for research or therapy. Research on pluripotent stem cells spans the molecular control of pluripotency, directed differentiation and applied uses in modelling and screening. Studies in this journal's corpus examine the use of human iPSC-derived cardiomyocytes in cardiotoxicity and safety testing, including calcium-transient and in-vitro disease-model assays, and the regulation of pluripotency-associated genes such as OCT4, including by microRNAs. Other work addresses biocompatible scaffolds for pluripotent stem cell transplantation and three-dimensional neural culture for modelling post-stroke recovery, the effects of anaesthetics on neural stem cells, and broader regenerative medicine and stem cell therapies. Related articles consider the molecular control of human embryonic development and the ethics of stem cell research. Together these aspects span pluripotency and reprogramming, differentiation, preclinical disease modelling and safety testing, and the regenerative and ethical dimensions of working with these versatile cells.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Pluripotent Stem Cells, linking to each citing work.