Reactive oxygen species (ROS) are chemically reactive molecules and ions derived from oxygen, including superoxide anion, hydrogen peroxide, and hydroxyl radicals, generated as natural by-products of cellular metabolism, particularly in the mitochondria during respiration. At controlled levels ROS act as signalling …
Reactive oxygen species (ROS) are chemically reactive molecules and ions derived from oxygen, including superoxide anion, hydrogen peroxide, and hydroxyl radicals, generated as natural by-products of cellular metabolism, particularly in the mitochondria during respiration. At controlled levels ROS act as signalling molecules involved in gene expression, cell proliferation, and host defence, but in excess they can oxidatively damage lipids, proteins, and nucleic acids, a state associated with oxidative stress. In the context of DNA And RNA Research, ROS are of particular interest because of their capacity to modify and damage genetic material and to influence redox-sensitive cellular processes. Studies collected here examine the redox potential of phytochemicals and their impact on DNA, the generation of superoxide during methylglyoxal-dependent cross-linking reactions, and the relationship between oxidative end products and inflammatory markers in patients undergoing hemodialysis. A substantial strand addresses antioxidant defence, including the radical-scavenging activities of natural and synthetic compounds, the protective effects of ozone therapy on mitochondria, and the role of antioxidant micronutrients in metabolic syndrome. Related work extends to cardiac cell models, plant responses to drought and salt stress, and reproductive biology. Together these topics reflect ROS as central mediators linking oxygen metabolism, oxidative damage to DNA and other macromolecules, antioxidant protection, and the regulation of cellular function across biological systems.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 102 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Reactive Oxygen Species, linking to each citing work.